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Key Documents

PHR1890

Supelco

Tiotropium bromide monohydrate

Pharmaceutical Secondary Standard; Certified Reference Material

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About This Item

Empirical Formula (Hill Notation):
C19H22BrNO4S2 · H2O
CAS Number:
Molecular Weight:
490.43
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. Y0001188

API family

tiotropium

CofA

current certificate can be downloaded

packaging

pkg of 50 mg

application(s)

pharmaceutical

format

neat

storage temp.

2-8°C

InChI

1S/C19H22NO4S2.BrH.H2O/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H;1H2/q+1;;/p-1/t11?,12-,13+,16-,17+;;

InChI key

MQLXPRBEAHBZTK-KFEMZTBUSA-M

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Tiotropium bromide monohydrate is structurally related to ipratropium bromide. It is a second-generation anticholinergic agent specific for muscarinic receptors (M1, M2 & M3) in humans.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Tiotropium bromide monohydrate may be used as a reference compound to investigate the role of M2 and M3 muscarinic receptors in the contraction of rat and human small airways.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB0347 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Certificates of Analysis (COA)

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