8.07491

Polyethylene glycol

6000, for synthesis

• Synonym(s): Poly(ethylene glycol), Polyethylene glycol 6000, Polyglycol, Polyethylene oxide, Polyoxy ethylene, PEG 6000, PEG
• Linear Formula: H(OCH₂CH₂)_nOH
• CAS Number: 25322-68-3
• MDL number: MFCD00081839
• UNSPSC Code: 13111021
• EC Index Number: 500-038-2
• NACRES: NA.22

Properties

• vapor pressure: <0.01 hPa ( 20 °C)
• Quality Level: 200
• form: solid
• autoignition temp.: 420 °C
• potency: 28000 mg/kg LD₅₀, oral (Rat); >20000 mg/kg LD₅₀, skin (Rabbit)
• pH: 5-7 (20 °C, 100 g/L in H₂O)
• mp: 58-63 °C
• transition temp: flash point 270 °C
• density: 1.2 g/cm³ at 20 °C
• storage temp.: 2-30°C
• SMILES string: C(CO)O
• InChI: 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
• InChI key: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Description

General description

Polyethylene glycol (PEG) is a synthetic, hydrophilic, biocompatible polymer that has a wide range of uses in PEGylation, surface conjugation, nanoparticle coating, and crosslinking for hydrogels, etc. PEGs are made by polymerizing ethylene oxide via a ring-opening reaction to produce a wide range of molecular weights and molecular weight distributions (polydispersity).

Application

Polyethylene glycol 6000 is a non-ionic surfactant that can be used as a structure-directing agent to prepare mesoporous γ-A_l2O₃. PEG 6000 induced the formation of the lamellate structure morphology of boehmite nanoparticles with improved textural properties such as high surface area, larger pore volume, and pore size. It is also used in drug formulations to enhance the dissolution rate of the poorly water-soluble drug molecule. PEG-6000 can also be used in the purification of nucleic acids via the selective precipitation method. This approach is economically cost-effective and faster than the commonly employed chromatographic purification method.

Analysis Note

Melting range (lower value): ≥ 59 °C
Melting range (upper value): ≤ 64 °C
Hydroxyl value: 16 - 23
Average molecular mass: 5000 - 7000
Identity (IR): passes test

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 281.5 °F - closed cup
• Flash Point(C): 138.6 °C - closed cup