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For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf
5.43899
NMP
for liquid chromatography LiChrosolv®
Synonym(s):
1-Methyl-2-pyrrolidone, NMP, N-Methyl-2-pyrrolidone
About This Item
Recommended Products
Product Name
1-Methyl-2-pyrrolidone, for liquid chromatography LiChrosolv®
vapor pressure
0.32 hPa ( 20 °C)
Quality Level
description
isocratic
product line
LiChrosolv®
Assay
≥99.5% (GC)
form
liquid
autoignition temp.
245 °C
expl. lim.
1.3-9.5 % (v/v)
technique(s)
HPLC: suitable
impurities
≤0.05% Water
transmittance
300 nm, ≥50%
325 nm, ≥90%
350 nm, ≥97%
400 nm, ≥99%
pH
8.5-10.0 (20 °C, 100 g/L in H2O)
bp
202 °C/1013 hPa
mp
-24 °C
transition temp
flash point 91 °C
solubility
1000 g/L
density
1.03 g/cm3 at 20 °C
storage temp.
2-30°C
SMILES string
N1(CCCC1=O)C
InChI
1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
InChI key
SECXISVLQFMRJM-UHFFFAOYSA-N
Application
- Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs artemether-lumefantrine: This study utilizes 1-Methyl-2-pyrrolidone (NMP) as a high-purity solvent in the formulation of a transdermal bioadhesive system, enhancing the solubility and delivery of antimalarial drugs. The application highlights NMP′s role in pharmaceutical formulations, particularly in improving drug efficacy and patient compliance (Volpe-Zanutto et al., 2021).
Analysis Note
Water: ≤ 0.05 %
Transmission (at 300 nm): ≥ 50 %
Transmission (at 325 nm): ≥ 90 %
Transmission (at 350 nm): ≥ 97 %
Transmission (at 400 nm): ≥ 99 %
Other Notes
Legal Information
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
Flash Point(F)
195.8 °F - Pensky-Martens closed cup
Flash Point(C)
91 °C - Pensky-Martens closed cup
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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