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855642

Sigma-Aldrich

N-Acetyl-L-glutamic acid

99%, for peptide synthesis, ReagentPlus®

Synonym(s):

(2S)-2-Acetamidopentanedioic acid, N-Acetylglutamic acid

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About This Item

Linear Formula:
HO2CCH2CH2CH(NHCOCH3)CO2H
CAS Number:
1188-37-0
Molecular Weight:
189.17
Beilstein:
1727473
EC Number:
214-708-4
MDL number:
MFCD00002802
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24888393
NACRES:
NA.22

product name

N-Acetyl-L-glutamic acid, ReagentPlus®, 99%

product line

ReagentPlus®

Assay

99%

form

powder

optical activity

[α]22/D −15.6°, c = 1 in H2O

reaction suitability

reaction type: solution phase peptide synthesis

mp

194-196 °C (lit.)

application(s)

peptide synthesis

storage temp.

2-8°C

SMILES string

CC(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C7H11NO5/c1-4(9)8-5(7(12)13)2-3-6(10)11/h5H,2-3H2,1H3,(H,8,9)(H,10,11)(H,12,13)/t5-/m0/s1

InChI key

RFMMMVDNIPUKGG-YFKPBYRVSA-N

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Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Vockley et al.
Biochemical medicine and metabolic biology, 47(1), 38-46 (1992-02-01)
N-Acetyl-L-glutamate synthetase (NAG synthetase) is a mitochondrial matrix enzyme which catalyzes the synthesis of N-acetyl-Lglutamate (NAG), a physiologic activator of the urea cycle enzyme carbamylphosphate synthetase I. Deficiency of NAG synthetase in humans has been reported only three times previously.
Jiguang Wang et al.
Poultry science, 99(7), 3583-3593 (2020-07-04)
The present study determined the effects of in ovo feeding (IOF) of N-acetyl-L-glutamate (NAG) on early intestinal development and growth performance of broilers. A total of 702 fertile broiler eggs were randomly divided into 3 treatments: 1) non-punctured control group
W Zhang et al.
Clinical and investigative medicine. Medecine clinique et experimentale, 13(4), 183-188 (1990-08-01)
Liver tissue from 3 patients with carbamyl phosphate synthetase I deficiency and 11 patients with ornithine transcarbamylase deficiency was analyzed by Western blots for the presence of carbamyl phosphate synthetase I and ornithine transcarbamylase cross-reactive material with anti-rat enzyme antibodies.
M Tuchman et al.
Pediatric research, 27(4 Pt 1), 408-412 (1990-04-01)
N-acetylglutamate (NAG) content was measured in homogenates of liver and small intestine obtained from normal and 24-h starved syngeneic mice. Subsequently, NAG was determined in normal, and in carbamyl phosphate synthetase I and ornithine transcarbamylase enzyme-deficient human liver tissue homogenates.
K Sugahara et al.
Journal of chromatography. B, Biomedical applications, 657(1), 15-21 (1994-07-01)
Liquid chromatography-atmospheric pressure chemical-ionization mass spectrometry (LC-APCI-MS) was used for the analysis of N-acetylamino acids that could not be determined with an amino acid analyzer. LC-APCI-MS could directly detect the protonated molecular ions of various synthetic N-acetylamino acids, distinguishing N-acetylserine
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