- Protein Kinase A Deregulation in the Medial Prefrontal Cortex Impairs Working Memory in Murine Oligophrenin-1 Deficiency.
Protein Kinase A Deregulation in the Medial Prefrontal Cortex Impairs Working Memory in Murine Oligophrenin-1 Deficiency.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017-10-17)
Chun-Lei Zhang, Mattia Aime, Emilie Laheranne, Xander Houbaert, Hajer El Oussini, Christelle Martin, Marilyn Lepleux, Elisabeth Normand, Jamel Chelly, Etienne Herzog, Pierre Billuart, Yann Humeau
PMID29030432
ABSTRACT
Classical and systems genetics have identified wide networks of genes associated with cognitive and neurodevelopmental diseases. In parallel to deciphering the role of each of these genes in neuronal or synaptic function, evaluating the response of neuronal and molecular networks to gene loss of function could reveal some pathophysiological mechanisms potentially accessible to nongenetic therapies. Loss of function of the Rho-GAP oligophrenin-1 is associated with cognitive impairments in both human and mouse. Upregulation of both PKA and ROCK has been reported in
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