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Merck

A highly selective, organocatalytic route to chiral 1,2-oxazines from ketones.

Chemical communications (Cambridge, England) (2006-10-10)
Sirirat Kumarn, David M Shaw, Steven V Ley
ABSTRACT

A sequential, organocatalysed asymmetric reaction to access chiral 1,2-oxazines from achiral ketone starting materials is reported, which proceeds in moderate to good yields and excellent enantioselectivity.

MATERIALI
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Sigma-Aldrich
(S)-5-(–)-(2-Pyrrolidinyl)-1H-tetrazole, 96%