First diastereoselective chiral synthesis of (-)-securinine.

First diastereoselective chiral synthesis of (-)-securinine.

Organic letters (2004-01-03)

Toshio Honda, Hidenori Namiki, Kyosuke Kaneda, Hirotake Mizutani

ABSTRACT

[reaction: see text] A diastereoselective total synthesis of securinine in optically pure form was achieved by employing ring-closing metathesis of the corresponding dienyne compound as a key step.

MATERIALI

N° Catalogo

Marchio

Descrizione del prodotto

419591

Sigma-Aldrich

3-Butenylmagnesium bromide solution, 0.5 M in THF