- On-demand controlled release of anti-inflammatory and analgesic drugs from conducting polymer films to aid in wound healing.
On-demand controlled release of anti-inflammatory and analgesic drugs from conducting polymer films to aid in wound healing.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference (2013-02-01)
Gusphyl A Justin, Siqiang Zhu, Theodore R Nicholson, Jeffrey Maskrod, Joseph Mbugua, Mark Chase, June-ho Jung, Ramil Marcelo L Mercado
PMID23366114
ABSTRACT
An electronically-controlled drug delivery system (eDDS) for the on-demand release of anti-inflammatory, anti-microbial and analgesic agents to aid in wound healing is currently under development. The loading of several drugs into conductive polymer films and their subsequent on-demand, controlled release upon application of an electrical potential to the polymer film has been demonstrated. The loading and release (active and passive) of Ibuprofen sodium salt - a negatively charged analgesic and anti-inflammatory agent - from polypyrrole films is described. Major challenges identified include precise control over drug loading and passive release from the conducting polymers in the absence of an applied potential.
MATERIALI
N° Catalogo
Marchio
Descrizione del prodotto
Sigma-Aldrich
Polypyrrole, doped, conductivity 30 S/cm (bulk), extent of labeling: 20 wt. % loading, composite with carbon black
Sigma-Aldrich
Polypyrrole, doped, conductivity 0.5-1.5 S/cm (pressed pellet, typical), extent of labeling: ~5 wt. % loading, coated on titanium dioxide