Passa al contenuto
Merck

Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines.

Bioorganic & medicinal chemistry (2008-02-26)
Stanton Hon Lung Kok, Roberto Gambari, Chung Hin Chui, Marcus Chun Wah Yuen, Eva Lin, Raymond Siu Ming Wong, Fung Yi Lau, Gregory Yin Ming Cheng, Wing Sze Lam, Sau Hing Chan, Kim Hung Lam, Chor Hing Cheng, Paul Bo Shan Lai, Michael Wing Yiu Yu, Filly Cheung, Johnny Cheuk On Tang, Albert Sun Chi Chan
ABSTRACT

Phthalic anhydride is a highly toxic substance, facing, however, the problem of hydrolysis. In fact, it is rapidly hydrolyzed in aqueous medium, generating phthalic acid as the final product, which is almost harmless to viable cells. Here we describe the 'one pot' condensation reaction for the synthesis of phthalic imide derivative (benzothiazole containing phthalimide), exhibiting in vitro cytotoxic potential on human cancer cell lines. We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells.

MATERIALI
N° Catalogo
Marchio
Descrizione del prodotto

Sigma-Aldrich
Phthalimide, ≥99%
Sigma-Aldrich
Phthalimide potassium salt, 98%
Sigma-Aldrich
Phthalimide potassium salt, purum, ≥99.0% (NT)