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Synthesis and activity of 2-oxoamides containing long chain beta-amino acids.

Journal of peptide science : an official publication of the European Peptide Society (2005-01-07)
Violetta Constantinou-Kokotou, Anna Peristeraki, Christoforos G Kokotos, David A Six, Edward A Dennis
ABSTRACT

2-Oxoamides based on long chain beta-amino acids were synthesized. 1-Benzyl substituted long chain amines, needed for such synthesis, were synthesized starting from Boc-phenylalaninol. The oxidative conversion of a phenyl group to a carboxyl group was used as the key transformation synthetic step. The compounds synthesized were studied for their activity against GIVA PLA(2), and were proven to be weak inhibitors.

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Sigma-Aldrich
(S)-(−)-2-Amino-3-phenyl-1-propanol, 98%, optical purity ee: 99% (HPLC)