- Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.
Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.
Nature structural & molecular biology (2011-11-15)
Ivan V Rosado, Frédéric Langevin, Gerry P Crossan, Minoru Takata, Ketan J Patel
PMID22081012
ABSTRACT
Metabolism is predicted to generate formaldehyde, a toxic, simple, reactive aldehyde that can damage DNA. Here we report a synthetic lethal interaction in avian cells between ADH5, encoding the main formaldehyde-detoxifying enzyme, and the Fanconi anemia (FA) DNA-repair pathway. These results define a fundamental role for the combined action of formaldehyde catabolism and DNA cross-link repair in vertebrate cell survival.