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Merck

A new sesquiterpene lactone from Artemisia rubripes nakai.

Archives of pharmacal research (2004-11-24)
Kyu Ha Lee, Yong Deuk Min, Sang Zin Choi, Hak Cheol Kwon, Ock Ryun Cho, Kang Choon Lee, Kang Ro Lee
ABSTRACT

The chromatographic separation of a methylene chloride extract of Artemisia rubripes led to the isolation of a new sesquiterpene lactone (3), together with four known compounds, a coumarin (2) and three terpenes (1, 4, and 5). Their structures were characterized to be 1beta,6alpha-dihydroxy-4(15)-eudesmene (1), scopoletin (2), 1alpha,4beta-dihydroxy-8alpha-acetoxy-guaia-2,10(14), 11(13)-triene-6,12-olide (3), 1alpha,4beta-dihydroxy-8alpha-acetoxy-guaia-2,9,11(13)-triene-6,12-olide (4), and beta-sitosterol-3-O-beta-D-glycoside (5) by spectroscopic means.