- Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears.
Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears.
Antimicrobial agents and chemotherapy (2007-05-23)
A H Diacon, R F Patientia, A Venter, P D van Helden, P J Smith, H McIlleron, J S Maritz, P R Donald
PMID17517849
ABSTRACT
We studied the early bactericidal activity of twice the standard dose of rifampin in subjects with pulmonary tuberculosis evidenced by positive smears. The observed mean 2-day activity was almost double that reported at the standard dose. Further studies are warranted to establish whether higher rifampin doses might assist in shortening tuberculosis treatment.