- Two distinct epitopes on the ovalbumin 323-339 peptide differentiating CD4⁺T cells into the Th2 or Th1 phenotype.
Two distinct epitopes on the ovalbumin 323-339 peptide differentiating CD4⁺T cells into the Th2 or Th1 phenotype.
Bioscience, biotechnology, and biochemistry (2012-10-11)
Haruyo Nakajima-Adachi, Emiko Koike, Mamoru Totsuka, Erika Hiraide, Yoshio Wakatsuki, Hiroshi Kiyono, Satoshi Hachimura
PMID23047087
ABSTRACT
The epitopes for OVA323-339-specific CD4⁺T cells from OVA23-3 food allergy model and DO11.10 tolerant induction model mice were analyzed. We found that OVA23-3 CD4⁺T cells recognized the N-terminal region, showing strong proliferation and the Th2-phenotype, and that DO11.10 CD4⁺T cells recognized the C-terminal region, showing milder proliferation and a Th1-skewed response. These differences may regulate the responses of those mice to OVA-feeding, inflammation and tolerance.
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