V6629

Vitamina B₁₂

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%

• Sinonimo/i: α-(5,6-dimetilbenzimidazolil)cianocobamide, CN-Cbl, Cianocob(III)alamina, Cianocobalamina
• Formula empirica (notazione di Hill): C₆₃H₈₈CoN₁₄O₁₄P
• Numero CAS: 68-19-9
• Peso molecolare: 1355.37
• Beilstein: 4122889
• Numero CE: 200-680-0
• Codice UNSPSC: 12352205
• eCl@ss: 34058004
• ID PubChem: 24900763
• NACRES: NA.75

Proprietà

• Origine biologica: synthetic ((organic))
• Livello qualitativo: 200
• Nome Commerciale: BioReagent
• Saggio: ≥98%
• Forma fisica: powder
• PM: M_w 1355.37 g/mol
• tecniche: cell culture | insect: suitable; cell culture | mammalian: suitable; cell culture | plant: suitable
• Colore: red to brown
• pH: 6
• Solubilità: water: soluble 50 mg/mL, dark red
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@
• InChI: 1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1; RMRCNWBMXRMIRW-QJRSUKKJSA-L

Descrizione

Descrizione generale

Cyanocobalamin (B12) is a water soluble vitamin, commonly called as cobalamins. Dairy products, meat and eggs are the major sources of this vitamin.

Applicazioni

Vitamin B12 has been used:

• as a component of Erdschreiber′s medium
• as a supplement of Dulbecco′s modified Eagle′s medium used for the isolation of ventricular myocytes from neonatal and adult rats
• orally administered to male quails to study its role in reducing the negative effects of sodium selenite intoxication, in vivo
• as a supplement in DMEM/ medium 199 (M199) medium for differentiation of human myoblasts.

Azioni biochim/fisiol

Vitamin B12 is metabolized to its active form, methylcobalamin. Hindered vitamin B12 uptake is observed in pernicious anemia. Vitamin B12 is essential for erythroblast development. Pregnancy reduces the levels of vitamin B12. Aging reduces vitamin B12 absorption. It works as a coenzyme in fat, carbohydrate and protein metabolism. It is required for growth, genetic stability and survival of cells in vitro. Functions to support one-carbon metabolism. Present in many classical and serum-free formulations.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)