T104

Tropisetron

solid, ≥98% (HPLC)

• Sinonimo/i: ICS-205,930, Navoban, endo-8-Methyl-8-azabicyclo[3.2.1]oct-3-ol Indol-3-yl-carboxylate
• Formula empirica (notazione di Hill): C₁₇H₂₀N₂O₂ · HCl
• Numero CAS: 105826-92-4
• Peso molecolare: 320.81
• NACRES: NA.77
• PubChem Substance ID: 24278133
• UNSPSC Code: 12352200
• MDL number: MFCD00210221
• Assay: ≥98% (HPLC)
• Form: solid

Proprietà

• assay: ≥98% (HPLC)
• form: solid
• solubility: H₂O: >10 mg/mL
• originator: Novartis
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN1C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34
• InChI: 1S/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H
• InChI key: XIEGSJAEZIGKSA-UHFFFAOYSA-N
• Gene Information: human ... CHRNA3(1136), CHRNA4(1137), CHRNB2(1141), CHRNB4(1143), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242) ; rat ... Chrna7(25302), Drd2(24318), Htr1a(24473), Htr3a(79246)

Descrizione

Application

Tropisetron monohydrochloride was used as a standard to determine the tropisetron in human plasma using HPLC method with UV detection.[1]

Biochem/physiol Actions

3-Tropanylindole-3-carboxylate hydrochloride is a selective 5-HT₃ serotonin receptor antagonist.

Selective 5-HT₃ serotonin receptor antagonist.

Tropisetron a selective serotonin 5-HT₃ receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)