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S2822

Sigma-Aldrich

Anti-Synapsin II

enhanced validation

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-SYN2, Anti-SYNAPSIN 2, Anti-SYNII, Anti-SYNIIa, Anti-SYNIIb

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen ~54 kDa (synapsin IIb)
antigen ~74 kDa (synapsin IIa)

Reattività contro le specie

mouse, human, rat

Convalida avanzata

recombinant expression
Learn more about Antibody Enhanced Validation

Concentrazione

~1 mg/mL

tecniche

western blot: 0.5-1 μg/mL using extracts of HEK-293T cells expressing recombinant human synapsin II, mouse brain extract (S1 fraction), and rat PC12 cell lysate

N° accesso UniProt

Q92777

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... SYN2(6854)
mouse ... Syn2(20965)
rat ... Syn2(29179)

Descrizione generale

Synapsin II (SYN-2) is a neuronal phosphoprotein present in synaptic vesicles. The SYN-2 gene is mapped to human chromosome 3p25.2. Structurally, synapsin types have a conserved N -terminal region and vary in their C-terminal region.

Specificità

Anti-Synapsin II specifically recognizes human, rat, and mouse synapsin IIa and Iib.

Immunogeno

synthetic peptide corresponding to amino acids 438-453 located near the C-terminus of rat synapsin II, conjugated to KLH. This sequence is identical in rat synapsin IIa and IIb isoforms and mouse synapsin II, and is highly conserved in human synapsin IIa and IIb (one amino acid substitution).

Applicazioni

Anti-Synapsin II antibody produced in rabbit may be used in immunoblotting.

Azioni biochim/fisiol

Synapsins regulate synaptic vesicle clustering, neurotransmitter release, and the formation of synaptic terminals. Synapsin II is involved in the formation of synaptic terminals during neuronal development. Similar to synapsin I, synapsin II can link synaptic vesicles to the actin cytoskeleton, thus regulating the availability of synaptic vesicles for exocytosis. Synapsin II association with synaptic vesicles is controlled by phosphorylation. Synapsin II is proposed as a candidate associated with increased vulnerability to schizophrenia. It is also implicated in synaptogenesis and neurotransmitter release impairment in multiple neuropsychiatric diseases.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Stoccaggio e stabilità

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificati d'analisi (COA)

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Qi Chen et al.
American journal of human genetics, 75(5), 873-877 (2004-09-28)
Synapsin II has been proposed as a candidate gene for vulnerability to schizophrenia on the basis of its function and its location in a region of the genome implicated by linkage studies in families with schizophrenia. We recently reported positive
A Ferreira et al.
Molecular medicine (Cambridge, Mass.), 4(1), 22-28 (1998-03-26)
The synapsins are a family of neuron-specific proteins, associated with the cytoplasmic surface of synaptic vesicles, which have been shown to regulate neurotransmitter release in mature synapses and to accelerate development of the nervous system. Using neuronal cultures from mice
Seong-Yeon Bae et al.
Experimental neurobiology, 26(2), 82-89 (2017-04-27)
Translationally controlled tumor protein (TCTP) is a cytosolic protein with microtubule stabilization and calcium-binding activities. TCTP is expressed in most organs including the nervous system. However, detailed distribution and functional significance of TCTP in the brain remain unexplored. In this
G Thiel et al.
The Journal of biological chemistry, 265(27), 16527-16533 (1990-09-25)
The synapsins are a family of neuron-specific phosphoproteins that selectively bind to small synaptic vesicles in the presynaptic nerve terminal. Using the cDNA encoding rat synapsin IIb, we employed an Escherichia coli expression system to synthesize a variety of fusion
Yuhai Zhao et al.
Frontiers in cellular neuroscience, 13, 314-314 (2019-07-30)
Trans-synaptic neurotransmission of both electrical and neurochemical information in the central nervous system (CNS) is achieved through a highly interactive network of neuron-specific synaptic proteins that include pre-synaptic and post-synaptic elements. These elements include a family of several well-characterized integral-

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