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Merck
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P4484

Sigma-Aldrich

Purvalanol A

≥98% (HPLC), powder

Sinonimo/i:

2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-60

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About This Item

Formula empirica (notazione di Hill):
C19H25ClN6O
Numero CAS:
212844-53-6
Peso molecolare:
388.89
Numero MDL:
MFCD02179211
Codice UNSPSC:
12352200
ID PubChem:
24898543
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

powder

Solubilità

methylene chloride: 50 mg/mL

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c3ncn(C(C)C)c3n1

InChI

1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
PMXCMJLOPOFPBT-HNNXBMFYSA-N

Azioni biochim/fisiol

Purvalanol A is found to inhibit ABCG2 (ATP-binding cassette G2) transporter in vitro. It is also known to attenuate cellular Src kinase action and induce cell cycle arrest at the G2 to M phase transition.
Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor.

Caratteristiche e vantaggi

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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