L2913

Leptomycin B

from Streptomyces sp., ≥95% (HPLC), solution, nuclear transport inhibitor

• Sinonimo/i: Antibiotic CI 940, Elactocin, LMB, Mantuamycin
• Formula empirica (notazione di Hill): C₃₃H₄₈O₆
• Numero CAS: 87081-35-4
• Peso molecolare: 540.73
• UNSPSC Code: 12352200
• PubChem Substance ID: 24896330
• NACRES: NA.77
• MDL number: MFCD06795848
• Assay: ≥95% (HPLC)
• Storage condition: protect from light

Proprietà

• Nome del prodotto: Leptomycin B solution from Streptomyces sp., ≥95% (HPLC), Supplied in methanol: water (7:3)
• Quality Segment: 300
• assay: ≥95% (HPLC)
• storage condition: protect from light
• antibiotic activity spectrum: fungi
• mode of action: protein synthesis | interferes
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CCC(\C=C\[C@@H]1OC(=O)C=C[C@@H]1C)=C\[C@H](C)C\C=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O
• InChI: 1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1
• InChI key: YACHGFWEQXFSBS-XYERBDPFSA-N

Descrizione

General description

Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, I?B, MPF, PKA and MEK.

Biochem/physiol Actions

Leptomycin B is an unsaturated, branched-chain fatty acid, and is an important tool in the study of nuclear export. Leptomycin B is a specific inhibitor of proteins containing nuclear export signal. Leptomycin B inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. The addition of very small amounts to fibroblasts causes accumulation of MEK in the nucleus. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, IκB, MPF, and PKA. The suggested inhibition mechanism involves the direct binding of leptomycin B to CRM1, which blocks the binding of CRM1 to proteins containing the nuclear export signal, via the interaction with cysteine residue in CRM1 control conserved region.

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

Informazioni sulla sicurezza

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes
• Classe di stoccaggio: 3 - Flammable liquids
• wgk: WGK 2
• flash_point_f: 64.4 °F - closed cup
• flash_point_c: 18 °C - closed cup