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Merck
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Documenti

E8375

Sigma-Aldrich

Eserine

Sinonimo/i:

Physostigmine

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About This Item

Formula empirica (notazione di Hill):
C15H21N3O2
Numero CAS:
57-47-6
Peso molecolare:
275.35
Beilstein:
91230
Numero CE:
200-332-8
Numero MDL:
MFCD00151090
Codice UNSPSC:
12352200
ID PubChem:
24277867

Saggio

≥99% (HPLC)

Punto di fusione

102-104 °C (lit.)

Stringa SMILE

[H][C@]12N(C)CC[C@@]1(C)c3cc(OC(=O)NC)ccc3N2C

InChI

1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1
PIJVFDBKTWXHHD-HIFRSBDPSA-N

Informazioni sul gene

human ... ACHE(43) , APP(351) , BCHE(590)
mouse ... Ache(11423) , Bche(12038) , Chrm1(12669)
rat ... Ache(83817) , Bche(65036) , Chrm2(81645)

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Azioni biochim/fisiol

Acetylcholinesterase inhibitor that crosses the blood-brain barrier and forms a carbamylated enzyme complex with acetyl cholinesterase that degrades slowly.

Caratteristiche e vantaggi

This compound is featured on the Acetylcholine Receptors (Nicotinic) and Acetylcholine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300 + H330

Classi di pericolo

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Codice della classe di stoccaggio

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Ciaran G Carolan et al.
Journal of medicinal chemistry, 51(20), 6400-6409 (2008-09-27)
In this study, we report the SAR and characterization of two groups of isosorbide-based cholinesterase inhibitors. The first was based directly on the clinically used nitrate isosorbide mononitrate (ISMN) retention of the 5-nitrate group and introduction of a series of
Federica Belluti et al.
Journal of medicinal chemistry, 48(13), 4444-4456 (2005-06-25)
In continuing research that led us to identify a new class of carbamate derivatives acting as potent (Rampa et al. J. Med. Chem. 1998, 41, 3976) and long-lasting (Rampa et al. J. Med. Chem. 2001, 44, 3810) acetylcholinesterase (AChE) inhibitors
Irina Esterlis et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(1), 78-82 (2012-11-20)
In vivo estimation of β(2)-nicotinic acetylcholine receptor availability with molecular neuroimaging is complicated by competition between the endogenous neurotransmitter acetylcholine and the radioligand (123)I-3-[2(S)-2-azetidinylmethoxy]pyridine ((123)I-5-IA). We examined whether binding of (123)I-5-IA is sensitive to increases in extracellular levels of acetylcholine
Ciaran G Carolan et al.
Journal of medicinal chemistry, 53(3), 1190-1199 (2010-01-14)
Isosorbide-2-benzyl carbamate-5-benzoate is a highly potent and selective BuChE inhibitor. Meanwhile, isosorbide-2-aspirinate-5-salicylate is a highly effective aspirin prodrug that relies on the salicylate portion to interact productively with human BuChE. By integrating the salicylate group into the carbamate design, we
Anna M Lilja et al.
PloS one, 8(1), e54887-e54887 (2013-02-06)
Neuronal dysfunction and demise together with a reduction in neurogenesis are cardinal features of Alzheimer's disease (AD) induced by a combination of oxidative stress, toxic amyloid-β peptide (Aβ) and a loss of trophic factor support. Amelioration of these was assessed
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