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D4071

Sigma-Aldrich

5, 15-DPP

Sinonimo/i:

5,15-Diphenyl-21H,23H-porphine, 5,15-Diphenylporphyrin, 5,15-diphenyl-Porphine

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10 MG
80,60 €
50 MG
314,00 €

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Cambia visualizzazione
10 MG
80,60 €
50 MG
314,00 €

About This Item

Formula empirica (notazione di Hill):
C32H22N4
Numero CAS:
Peso molecolare:
462.54
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77

80,60 €


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Stato

powder

Stringa SMILE

c1ccc(cc1)-c2c3ccc(cc4ccc([nH]4)c(-c5ccccc5)c6ccc(cc7ccc2[nH]7)n6)n3

InChI

1S/C32H22N4/c1-3-7-21(8-4-1)31-27-15-11-23(33-27)19-25-13-17-29(35-25)32(22-9-5-2-6-10-22)30-18-14-26(36-30)20-24-12-16-28(31)34-24/h1-20,33,36H/b23-19-,24-20-,25-19-,26-20-,31-27-,31-28-,32-29-,32-30-
FNNOEKVUXXVPAI-DUVOQLPESA-N

Applicazioni

5, 15-DPP has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:
  • to analyze its effects on malignant peripheral nerve sheath tumor (MPNST) survival and proliferation[1]
  • to study its effects on the thymic stromal lymphopoietin (TSLP) modulation of nometastatic gene 23-H1 (NME1 or nm23-H1) expression in human trophoblasts[2]
  • to study its effects on 17β-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced M2 polarization in human macrophages and endometrial stromal cells[3]

Azioni biochim/fisiol

5, 15-DPP is a selective STAT3 inhibitor and a selective STAT3-SH2 antagonist

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Ying Wang et al.
Clinical immunology (Orlando, Fla.), 143(1), 88-95 (2012-03-01)
Our previous study has demonstrated that TSLP induces the invasion of human trophoblasts and plays a role in embryo implantation. The present study is undertaken to explore the mechanism by which TSLP modulates trophoblast invasion. It was revealed that TSLP
Yun Wang et al.
PloS one, 10(5), e0125559-e0125559 (2015-05-08)
The goal of this study is to elucidate the effects of 17β-estradiol and TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) on macrophage phenotypes in the endometriotic milieu. Co-culture of endometrial stromal cells (ESCs) and U937 cells (macrophage cell line) was performed to simulate the endometriotic
Jody Fromm Longo et al.
Cell communication and signaling : CCS, 17(1), 74-74 (2019-07-12)
We have found that erbB receptor tyrosine kinases drive Ras hyperactivation and growth in NF1-null malignant peripheral nerve sheath tumors (MPNSTs). However, MPNSTs variably express multiple erbB receptors with distinct functional characteristics and it is not clear which of these
Shaoxue Zeng et al.
Theranostics, 12(15), 6705-6722 (2022-10-04)
Rationale: Müller cells play an essential role in maintaining the health of retinal photoreceptors. Dysfunction of stressed Müller cells often results in photoreceptor degeneration. However, how these cells communicate under stress and the signalling pathways involved remain unclear. In this

Domande

  1. In which solvents is 5,15 DPP dissolved?

    1 risposta
    1. The solubility of the product is not tested as this is not a part of the product specification.
      However, not the same product, but product #573109, under the same CAS number had a solubility: DMSO (<1 mg/ml).

      Utile?

Recensioni

Nessuna valutazione

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