C7861

Citalopram hydrobromide

≥98% (HPLC), powder, serotonin uptake inhibitor

• Sinonimo/i: 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
• Formula empirica (notazione di Hill): C₂₀H₂₁FN₂O · HBr
• Numero CAS: 59729-32-7
• Peso molecolare: 405.30
• Numero CE: 261-890-6
• Numero MDL: MFCD02101306
• Codice UNSPSC: 12352200
• ID PubChem: 24278335
• NACRES: NA.77

Proprietà

• product name: Citalopram hydrobromide, ≥98% (HPLC)
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Solubilità: chloroform: soluble; methanol: soluble
• Ideatore: Forest Labs
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
• InChI: 1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H; WIHMBLDNRMIGDW-UHFFFAOYSA-N
• Informazioni sul gene: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

Descrizione

Descrizione generale

Citalopram is a bicyclic phthalene derivative. It initiates serotonergic activity, which produces antidepressant action. Citalopram hydrobromide reverses memory impairment. It is used to treat obsessive compulsive disorder, panic disorder, sociophobia and premenstrual dysphoric disorder.

Applicazioni

Citalopram hydrobromide has been used:

• to examine its effects on sirt mRNA and mammalian sirtuins (SIRT) expression in mice
• to monitor body temperature and antidepressant-like behavioral responses in the forced swim test for rats
• for 5-hydroxytryptamine (5-HT) competition uptake assays

Azioni biochim/fisiol

Potent and selective serotonin uptake inhibitor (K_i = 5.4 nM); antidepressant

Caratteristiche e vantaggi

This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H336,H361d,H412
• Consigli di prudenza: P202 - P261 - P264 - P273 - P301 + P312 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3
• Organi bersaglio: Central nervous system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)