C6895

Cefaclor

• Sinonimo/i: 7-(D-2-Amino-2-phenylacetamido)-3-chloro-3-cephem-4-carboxylic acid
• Formula empirica (notazione di Hill): C₁₅H₁₄ClN₃O₄S
• Numero CAS: 53994-73-3
• Peso molecolare: 367.81
• Beilstein: 8176092
• Numero CE: 258-909-5
• Numero MDL: MFCD00151471
• Codice UNSPSC: 51283701
• ID PubChem: 24278331
• NACRES: NA.85

Proprietà

• Stato: powder or crystals
• Solubilità: soluble (slightly soluble in water, practically insoluble in methanol, ethanol)
• Spettro attività antibiotica: Gram-negative bacteria; Gram-positive bacteria
• Modalità d’azione: cell wall synthesis | interferes
• Stringa SMILE: N[C@@H](C(=O)N[C@H]1[C@H]2SCC(Cl)=C(N2C1=O)C(O)=O)c3ccccc3
• InChI: 1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1; QYIYFLOTGYLRGG-GPCCPHFNSA-N

Descrizione

Descrizione generale

Chemical structure: ß-lactam

Applicazioni

Cefaclor has been used in the heterologous expression of AaOr7 and AaOr8 in Xenopus laevis oocytes.[1] It has also been used in cultures of isolated trigeminal ganglion (TG) and dorsal root ganglion (DRG) neurons.[2]

Cefaclor is used to study urinary tract, intra-abdominal, and Haemophilus influenzae infections [3][4][5]. It is used to study the mechanism of human renal organic anion and peptide transporters such as hOAT1, hPEPT1, and hPEPT2 and to study the effects of inhibition of penicillin-binding proteins on bacterial cell wall mucopeptide synthesis [6].

Azioni biochim/fisiol

Cefaclor is a second generation cephalosporin with broad spectrum activity against Gram-negative and Gram-positive bacteria. It binds to penicillin-binding proteins and thereby inhibits the cell wall synthesis causing cell death.[3]

Altre note

Keep container tightly closed in a dry and well-ventilated place. Slightly soluble in water, practically insoluble in methanol, chloroform and benzene.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves