C0733
Cyclooxygenase 1 from sheep
glycerol solution, ≥1500 units/mg protein
Sinonimo/i:
COX-1, Constitutive cyclooxygenase, Prostaglandin H synthase 1, Prostaglandin endoperoxide synthase
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Cambia visualizzazione
| A voi/SKU | Disponibilità | Prezzo |
|---|---|---|
5000 units | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 1.190,00 € |
Informazioni su questo articolo
Specific activity:
≥1500 units/mg protein
1.190,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Servizio Tecnico
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Permettici di aiutartiform
glycerol solution
Quality Segment
specific activity
≥1500 units/mg protein
mol wt
dimer subunit mol wt 70 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
sheep ... COX1(808251)
General description
Cyclooxygenase 1 is a 71 kDa membrane bound protein predominantly present in endoplasmic reticulum. It has three domains, the epidermal growth factor (EGF) like domain, enzymatic and membrane binding domain. Cyclooxygenase 1 mediates prostaglandin synthesis and is modulated by anti inflammatory nonsteroidal drugs.
Application
Cyclooxygenase 1 from sheep has been used as positive control protein in western blot analysis of osteoarthritis samples and in prostaglandin synthase activity assay.
Biochem/physiol Actions
COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively expressed in almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid.
Physical form
Solution in 80 mM Tris-HCl, pH 8, with 0.1% TWEEN® 20, 300 μM diethyldithiocarbamate and 10% glycerol.
Other Notes
One unit consumes one nanomole of oxygen per minute at 37 °C in 0.1 M Tris-HCl buffer, pH 8, containing 100 μM arachidonate, 5 mM EDTA, 2 mM phenol, and 1 μM hematin.
Legal Information
TWEEN is a registered trademark of Croda International PLC
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Questo articolo | |||
|---|---|---|---|
| specific activity ≥1500 units/mg protein | specific activity ≥8000 units/mg protein | specific activity - | specific activity - |
| Gene Information sheep ... COX1(808251) | Gene Information human ... PTGS2(5743) | Gene Information human ... COX1(6775083) | Gene Information human ... COX2(6775079) |
| form glycerol solution | form aqueous solution | form frozen liquid | form frozen liquid |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| mol wt dimer subunit mol wt 70 kDa | mol wt dimer subunit mol wt 70-74 kDa | mol wt 70.5 kDa | mol wt 71 kDa |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
Classe di stoccaggio
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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