Passa al contenuto
Merck
Tutte le immagini(1)

Documenti

B7777

Sigma-Aldrich

Budesonide

≥99%

Sinonimo/i:

16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C25H34O6
Numero CAS:
51333-22-3
Peso molecolare:
430.53
Numero CE:
257-139-7
Numero MDL:
MFCD00083259
Codice UNSPSC:
12352200
ID PubChem:
24278277
NACRES:
NA.77

Saggio

≥99%

Forma fisica

powder

Ideatore

AstraZeneca

Stringa SMILE

[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@H]5OC(CCC)O[C@@]45C(=O)CO

InChI

1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1
VOVIALXJUBGFJZ-KWVAZRHASA-N

Informazioni sul gene

human ... IFNG(3458) , IL5(3567) , NR3C1(2908)
rat ... Nr3c1(24413)

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Azioni biochim/fisiol

Budesonide is a second generation glucocorticoid with low systemic absorption. It is used as an anti-inflammatory agent in the treatment of asthma, rhinitis, and inflammatory bowel disease. It inhibits the expression of chemokine mRNA and production of eotaxin and RANTES protein in primary human bronchial epithelial cells. Budesonide is currently in clinical trials for the prevention of lung cancer. It shows inhibitory effects on benzo[a]pyrene-induced carcinogenesis of the lung in mice.

Caratteristiche e vantaggi

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H302,H317,H361d,H372,H412

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - Skin Sens. 1 - STOT RE 1 Inhalation

Organi bersaglio

Adrenal gland

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 8

1 of 8

Prednisone ≥98%

Sigma-Aldrich

P6254

Prednisone

USP

USP

1286107

Formoterol fumarate

Salmeterol xinafoate ≥98% (HPLC), solid

Sigma-Aldrich

S5068

Salmeterol xinafoate

Betamethasone ≥98%

Sigma-Aldrich

B7005

Betamethasone

Glycopyrronium bromide British Pharmacopoeia (BP) Reference Standard

BP1110

Glycopyrronium bromide

Beclomethasone dipropionate analytical standard, for drug analysis

Supelco

B3022

Beclomethasone dipropionate

Triamcinolone acetonide European Pharmacopoeia (EP) Reference Standard

T1900000

Triamcinolone acetonide

Ciclesonide ≥98% (HPLC)

Sigma-Aldrich

SML1955

Ciclesonide

Anne Bergeron et al.
American journal of respiratory and critical care medicine, 191(11), 1242-1249 (2015-04-04)
Systemic steroids are the standard treatment for bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) despite their poor efficacy and disabling side effects. To evaluate the effectiveness and tolerance of budesonide/formoterol as an alternative treatment for BOS
Sissie Wong et al.
Respiratory research, 10, 72-72 (2009-08-05)
There is currently a vast amount of evidence in the literature suggesting that matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are involved in the pathogenesis of inflammatory airways diseases, such as asthma and COPD. Despite this, the majority
Marek Woynarowski et al.
The Journal of pediatrics, 163(5), 1347-1353 (2013-07-03)
To compare the effect of budesonide vs prednisone therapy both in combination with azathioprine in pediatric patients with autoimmune hepatitis (AIH). Forty-six patients with AIH (11 males and 35 females) aged 9-17 years were enrolled in a 6-month, prospective, double-blind
Maciej Kupczyk et al.
Thorax, 68(7), 611-618 (2013-04-09)
Objective measures are required that may be used as a proxy for exacerbations in asthma. The aim was to determine the sensitivity and specificity of electronic diary data to detect severe exacerbations (SEs) of asthma. A secondary aim was to
James Fingleton et al.
The Journal of allergy and clinical immunology, 136(3), 601-609 (2015-03-10)
Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous disorders encompassing different phenotypes of airflow obstruction, which might differ in their response to treatment. The aim of this study was to determine distinct phenotypes comprising the syndromes of asthma and
Visualizza tutti i documenti correlati

Articoli

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.