A6604

A-350619 hydrochloride

≥98% (HPLC), solid

• Sinonimo/i: 3-[2-(4-Chlorophenylthio)phenyl]-N-(4-dimethylaminobutyl)acrylamide
• Formula empirica (notazione di Hill): C₂₁H₂₅ClN₂OS · HCl
• Numero CAS: 538368-27-3
• Peso molecolare: 425.41
• Numero MDL: MFCD06798332
• Codice UNSPSC: 41106305
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Colore: white
• Punto di fusione: 175.2-176.7 °C
• Solubilità: H₂O: 23 mg/mL
• Ideatore: Abbott
• Temperatura di conservazione: 2-8°C

Descrizione

Descrizione generale

Guanylyl cyclases are signal transduction enzyme that convert GTP to cyclic GMP. Soluble guanylate cyclase is activated by a gaseous ligand, nitric oxide.. The nitric oxide activation of soluble guanylate, resulting in GTP conversion to GMP, is important in physiological processes such as as smooth muscle relaxation, neurotransmission, inhibition of platelet aggregation and immune response. A-350619 is an activator of soluble guanylyl cyclase.

Applicazioni

A-350619 relaxes cavernosum tissue strips in a dose dependent manner with EC₅₀ of 80 μMM. Because A-350619 at 1 μMmol/kg induces penile erection in a conscious rat model, it may be useful as an alternate method of enhancing the effect of nitric oxide for the treatment of sexual dysfunction.

Azioni biochim/fisiol

A-350619 modulates catalytic properties of soluble guanylyl cyclase; it increases V_mas from 0.1 to 14.5 μmol/min/mg and lowers K_m from 300 to 50 μM. A-350619 activation of soluble guanylate cyclase depends on the presence of a heme moiety in the enzyme and synergy with nitric oxide.

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Note legali

Sold under license from Abbott Laboratories

Informazioni sulla sicurezza

• Pittogrammi: GHS05,GHS07,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H315,H318,H335,H410
• Consigli di prudenza: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves