Journal of toxicology and environmental health. Part A, 75(19-20), 1216-1225 (2012-09-22)
Long-term follow-ups on bladder cancer patients from highly industrialized areas are rare. Therefore, we present a follow-up of bladder cancer patients from the greater area Lutherstadt Wittenberg, a center of the chemical industry of the former German Democratic Republic. Relapse-free
The etiology of dermatological diseases is still unknown. Involvement of genetic and environmental factors in the pathogenesis of dermatological diseases has contributed to a number of studies whose aim is to elucidate the way in which xenobiotics exert effects on
Advances in pharmacology (San Diego, Calif.), 63, 169-205 (2012-07-11)
Arylamine N-acetyltransferases (NATs) are defined as xenobiotic metabolizing enzymes, adding an acetyl group from acetyl coenzyme A (CoA) to arylamines and arylhydrazines. NATs are found in organisms from bacteria and fungi to vertebrates. Several isoenzymes, often polymorphic, may be present
Expert opinion on drug metabolism & toxicology, 8(12), 1521-1530 (2012-09-25)
The quest for a biomarker that would reliably identify patients at risk of developing acute drug-induced liver injury (DILI) to a specific agent or class of agents before it occurs, has been underway for years. Historical host factors for DILI
Clinica chimica acta; international journal of clinical chemistry, 415, 215-219 (2012-10-27)
The relationship of NAT2, CYP2E1 and GSTM1/GSTT1 polymorphisms with mild elevation of liver biomarkers was investigated in individuals under anti-tuberculosis drug therapy. Tuberculosis outpatients (18-70 y) with (n=59) and without (n=40) mild increase of liver enzymes (MILE) at two-month treatment
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