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A4086

Anti-ATF-2 (SS-16) antibody produced in rabbit

Name: Anti-ATF-2 (SS-16) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

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About This Item

Numero MDL:

MFCD01092263

Codice UNSPSC:

12352203

NACRES:

NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 65 kDa

Reattività contro le specie

human

tecniche

immunoprecipitation (IP): 5 μg using lysates of human K562 cells
microarray: suitable
western blot (chemiluminescent): 1:250 using whole cell extract of human K562 or Jurkat cells

N° accesso UniProt

P15336

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ATF2(1386)

Categorie correlate

Primary Antibodies

Descrizione generale

ATF2 (Activating Transcription Factor 2, CRE-BP,HB-16, CREB2, TREB-7) belongs to the ATF/CREB family of basic region leucine zipper DNAbinding proteins. ATF2 regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Rabbit anti-ATF-2 (SS-16) antibody recognizes human ATF2 by immunoblotting (65kDa) and immunoprecipitation. Staining of ATF2 by immunoblotting is inhibited by the immunizing peptide.

Immunogeno

synthetic peptide corresponding to amino acids 490-505 of human ATF-2.

Applicazioni

Rabbit anti-ATF-2 can be used for immunoprecipitation (5μg, using lysates of human K562 cells), microarray, and chemiluminescent western blot (1:250, using whole cell extract of human K562 or Jurkat cells).

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Intramolecular inhibition of activating transcription factor-2 function by its DNA-binding domain.

X Y Li et al.

Genes & development, 10(5), 517-527 (1996-03-01)

ATF-2 is a cellular basic region-leucine zipper (bZIP) transcription factor that can mediate diverse transcriptional responses, including activation by the adenovirus Ela protein. ATF-2 contains an activation domain, required for transcriptional activity, but in the absence of an appropriate inducer

Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains.

F Liu et al.

Nature, 368(6471), 520-525 (1994-04-07)

A puzzling property of the transcriptional activators encoded by several animal viruses is their ability to function promiscuously. The adenovirus E1a protein, for example, stimulates transcription of adenoviral genes as well as a wide variety of other viral and cellular

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein.

F Liu et al.

Cell, 61(7), 1217-1224 (1990-06-29)

The adenovirus E1a protein stimulates transcription of viral early genes. Recent experiments indicate that E1a contains a transcriptional activating region, which functions when directed to a promoter. Because E1a is not a sequence-specific DNA binding protein, how it targets to

Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases.

H A Abdel-Hafiz et al.

Molecular endocrinology (Baltimore, Md.), 6(12), 2079-2089 (1992-12-01)

Recent studies have detailed the ability of activating transcription factor-2 (ATF-2) to mediate adenoviral E1a stimulation of gene expression; however, an endogenous regulator for the transcriptional activity of this protein has not been described. To characterize the regulation of ATF-2

Cdk1-mediated phosphorylation of human ATF7 at Thr-51 and Thr-53 promotes cell-cycle progression into M phase.

Hitomi Hasegawa et al.

PloS one, 9(12), e116048-e116048 (2014-12-30)

Activating transcription factor 2 (ATF2) and its homolog ATF7 are phosphorylated at Thr-69/Thr-71 and at Thr-51/Thr-53, respectively, by stress-activated MAPKs regulating their transcriptional functions in G1 and S phases. However, little is known about the role of ATF2 and ATF7

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