Passa al contenuto
Merck
Tutte le immagini(1)

Documenti

A3734

Sigma-Aldrich

1-Azakenpaullone

≥97% (HPLC)

Sinonimo/i:

9-Bromo-7,12-dihydro-pyrido[3′,2′:2,3]azepino[4,5-b]indol-6(5H)-one

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C15H10BrN3O
Numero CAS:
676596-65-9
Peso molecolare:
328.16
Numero MDL:
MFCD09037522
Codice UNSPSC:
12352200
ID PubChem:
329770845
NACRES:
NA.77

Saggio

≥97% (HPLC)

Forma fisica

powder

Condizioni di stoccaggio

protect from light

Colore

gray-brown

Solubilità

DMSO: >10 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C1CC2=C(NC3=C2C=C(Br)C=C3)C4=C(C=CC=N4)N1

InChI

1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
NTSBZVCEIVPKBJ-UHFFFAOYSA-N

Azioni biochim/fisiol

1-Azakenpaullone (AZP) can stimulate the transcription of β-catenin-related genes. This compound can induce the multiplication and replication of β cell.
1-Azakenpaullone is a cell permeable, potent, selective inhibitor of glycogen synthase kinase 3β (GSK3β) with 100-fold less cross-reactivity against CDKs. 1-Azakenpaullone can be used together with BIO and CHIR99021 as "gold standards" for GSK3 inhibition.

Avvertenza

air sensitive

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 5

1 of 5

SB 216763 >98% (HPLC)

Sigma-Aldrich

S3442

SB 216763

U0126 U0126, CAS 109511-58-2, is a potent and specific inhibitor of MEK1 (IC₅₀ = 72 nM) and MEK2 (IC₅₀ = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK.

Sigma-Aldrich

662005

U0126

Sigma-Aldrich

Sigma-Aldrich

D0547

Terreno Eagle modificato di Dulbecco/miscela nutritiva Ham F-12

IWR-1 ≥98% (HPLC)

Sigma-Aldrich

I0161

IWR-1

Dimethyl Sulfoxide Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1309

Dimethyl Sulfoxide

9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication
Stukenbrock H, et al.
Journal of medicinal chemistry, 51(7), 2196-2207 (2008)
Thiranut Jaroonwitchawan et al.
Biochemical and biophysical research communications, 481(1-2), 176-181 (2016-11-07)
Neural crest (NC) is a transient population, arising during embryonic development and capable of differentiating into various somatic cells. The defects of neural crest development leads to neurocristopathy. Several signaling pathways were revealed their significance in NC cell specification. Fibroblast
Rong Hu et al.
Stem cells translational medicine, 6(1), 121-130 (2017-02-09)
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for many malignant and nonmalignant diseases. However, chronic graft-versus-host disease (cGVHD) remains a significant cause of late morbidity and mortality after allogeneic HSCT. cGVHD often manifests as autoimmune syndrome.
Combination effects of AHR agonists and Wnt beta-catenin modulators in zebrafish embryos: implications for physiological and toxicological AHR functions
Wincent E, et al.
Toxicology and Applied Pharmacology, 284(2), 163-179 (2015)
Hiromi Takahashi et al.
Development genes and evolution, 229(2-3), 73-81 (2019-01-12)
Establishment of the body plan of multicellular organisms by the primary body axis determination and cell-fate specification is a key issue in biology. We have examined the mRNA localization of three Wnt pathway components gsk3β, β-catenin, and disheveled and investigated
Visualizza tutti i documenti correlati

Articoli

Glycogen Synthase Kinase 3 (GSK-3) Overview

Glycogen synthase kinase 3 (GSK-3) is a highly conserved family of serine/threonine kinases for over 100 proteins in many pathways. See a list of accepted GSK-3 modulators and related products.

PKB/Akt

We offer many products related to PKB/Akt for your research needs.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.