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Documenti

64951

Sigma-Aldrich

7-Methoxycoumarin

suitable for fluorescence, ≥98.0% (TLC)

Sinonimo/i:

Herniarin, Methyl umbelliferyl ether

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About This Item

Formula empirica (notazione di Hill):
C10H8O3
Numero CAS:
531-59-9
Peso molecolare:
176.17
Beilstein:
141728
Numero CE:
208-513-3
Numero MDL:
MFCD00006876
Codice UNSPSC:
85151701
ID PubChem:
57651999
NACRES:
NA.32

Saggio

≥98.0% (TLC)

Forma fisica

solid

Punto di fusione

117-121 °C (lit.)

Solubilità

DMF: soluble
acetonitrile: soluble
alcohols: soluble
chloroform: soluble

Fluorescenza

λex 350 nm; λem 385 nm (Reaction product)
λex 350 nm; λem 385 nm in chloroform

Compatibilità

suitable for fluorescence

Stringa SMILE

COc1ccc2C=CC(=O)Oc2c1

InChI

1S/C10H8O3/c1-12-8-4-2-7-3-5-10(11)13-9(7)6-8/h2-6H,1H3
LIIALPBMIOVAHH-UHFFFAOYSA-N

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Applicazioni

7-Methoxycoumarin (Herniarin) is used to study antioxidant and hepatoprotective properties and its activity as an allergen. 7-Methoxycoumarin may be used as a reference material in the purification, separation and analysis of coumarin compounds.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Sandesh Sancheti et al.
Drug and chemical toxicology, 36(1), 42-47 (2012-11-07)
The available conventional remedies for the treatment of drug-induced liver diseases are highly inadequate and possess serious adverse effects; therefore, the development of new, effective drugs is considered necessary. This article explores the hepatoprotective and antioxidant potential of 7-methylcoumarin (MC)
W Legrum et al.
The Journal of pharmacology and experimental therapeutics, 221(3), 790-794 (1982-06-01)
Pretreatment of rats with cobaltous chloride has been shown previously to reduce the content of cytochrome P-450 in the hepatic microsomal protein. This is accompanied by a corresponding decrease in substrate oxidation, e.g. ethyl morphine demethylation, in vitro. The present
P Paterson et al.
Xenobiotica; the fate of foreign compounds in biological systems, 14(11), 849-859 (1984-11-01)
Pretreatment of rats with phenobarbitone increased hepatic microsomal 7-methoxy-and 7-ethoxy-coumarin O-dealkylase activities. Pretreatment with beta-naphthoflavone increased only the 7-ethoxycoumarin O-dealkylase activity. The addition of metyrapone in vitro inhibited the O-dealkylations to different extents. Similar results were obtained with diphenyloxazole and
Chao-Mei Ma et al.
Phytochemical analysis : PCA, 18(1), 42-49 (2007-01-31)
A simple HPLC-PAD-MS method was established to quantitatively analyse two spiroether isomers (cis-en-yn-dicycloether and trans-en-yn-dicycloether) and the main coumarin, herniarin, in chamomile herbs, simultaneously. By using this method, the contents of these three compounds in the flowers of two chamomile
Adriana Eliasová et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 59(7-8), 543-548 (2005-04-09)
The responses of young plants of diploid and tetraploid Matricaria chamomilla cultivars to abiotic stress were studied. The course of quantitative changes of main leaf secondary metabolites was evaluated within an interval from 6 h before to 54 h after
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