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258024

Sigma-Aldrich

(±)-α-tocoferolo

≥95.5%

Sinonimo/i:

DL-all-rac-α-tocoferolo, Vitamina E

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About This Item

Formula empirica (notazione di Hill):
C29H50O2
Numero CAS:
10191-41-0
Peso molecolare:
430.71
Beilstein:
94012
Numero CE:
233-466-0
Numero MDL:
MFCD00006848
Codice UNSPSC:
12352205
eCl@ss:
34058016
ID PubChem:
57648149
NACRES:
NA.28

Origine biologica

synthetic

Saggio

≥95.5%

Forma fisica

liquid

tecniche

HPLC: suitable

Colore

faint brown to brown
 yellow to very dark yellow

Densità

0.950 g/mL at 20 °C (lit.)

applicazioni

cell analysis

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1

InChI

1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
GVJHHUAWPYXKBD-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

α-Tocopherol is the active form of vitamin E. It functions as an hydroperoxyl radical scavenger and protects the organism from oxidative damage. α-Tocopherol plays a crucial role in cell signalling and regulating immune responses. α-Tocopherol deficiency is associated with abetalipoproteinemia, cystic fibrosis and celiac disease. It has antiproliferative effects. It inhibits arsenite-induced damage of human fibroblasts.

Applicazioni

α-Tocopherol has been used:
  • as a standard to determine its concentration by reverse-phase high-performance liquid chromatography
  • to study its rescue effects on chlorine dioxide (ClO2) cytotoxicity
  • to assess its protective effects on acetaminophen (APAP)-mediated liver damage

Azioni biochim/fisiol

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

08168

Timestrip Plus™ 8 °C

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H317

Classi di pericolo

Skin Sens. 1

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Dispositivi di protezione individuale

Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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(±)-α-tocoferolo Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1031

(±)-α-tocoferolo

(+)-γ-Tocopherol ≥96% (HPLC)

Sigma-Aldrich

T1782

(+)-γ-Tocopherol

Αlfa tocoferolo United States Pharmacopeia (USP) Reference Standard

USP

1667600

Αlfa tocoferolo

DL-α-Tocopherol acetate ≥96% (HPLC)

Sigma-Aldrich

T3376

DL-α-Tocopherol acetate

DL-alpha-Tocopherol acetate analytical standard

Supelco

47786

DL-alpha-Tocopherol acetate

δ-Tocopherol analytical standard

Supelco

47784

δ-Tocopherol

(±)-α-tocoferolo 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-020

(±)-α-tocoferolo

(±)-α-tocoferolo dry powder, EMPROVE® ESSENTIAL, Ph. Eur., BP

SAFC

5.00878

(±)-α-tocoferolo

(+)-α-Tocopherol acetate BioReagent, suitable for insect cell culture, ~1360 IU/g

Sigma-Aldrich

T1157

(+)-α-Tocopherol acetate

(+)-γ-Tocopherol analytical standard

Supelco

47785

(+)-γ-Tocopherol

Early Diagnosis and Treatment of Cancer Series: Prostate Cancer E-Book: Expert Consult - Online and Print, 897-917 (2015)
Nutritional deficiencies and syndromes associated with alcoholism
Textbook of Clinical Neurology (Third Edition), 897-917 (2007)
Oxidative stress induced by chlorine dioxide as an insecticidal factor to the Indian meal moth, Plodia interpunctella
Kumar S, et al
Pesticide Biochemistry and Physiology, 124, 48-59 (2015)
Effect of vitamin E on oxidative stress level in blood, synovial fluid, and synovial tissue in severe knee osteoarthritis: a randomized controlled study
Tantavisut S, et al.
BMC Musculoskelet. Disord., 18(1), 281-281 (2017)
Glycosphingolipids Prevent APAP and HMG-CoA Reductase Inhibitors-mediated Liver Damage: A Novel Method for ?Safer Drug? Formulation that Prevents Drug-induced Liver Injury
Mizrahi M, et al.
Journal of clinical and translational hepatology, 6(2), 1-8 (2018)
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