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PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem

Name: PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem
Brand: MM

The PI 3-Kβ Inhibitor VI, TGX-221, also referenced under CAS 663619-89-4, controls the biological activity of PI 3-Kβ. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Sinonimo/i:

PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem, (±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one, PI 3-K Inhibitor VI

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Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₂₁H₂₄N₄O₂

Numero CAS:

663619-89-4

Peso molecolare:

364.44

UNSPSC Code:

12352200

Servizio Tecnico

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Proprietà

Quality Segment

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 10 mg/mL, ethanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Descrizione

General description

A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kβ (IC₅₀ = 0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 µM. An excellent tool for studying p110β-dependent responses both in cells in vitro and in animals in vivo.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PI 3-Kβ

Product competes with ATP.

Reversible: yes

Target IC₅₀: 0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively

Packaging

Packaged under inert gas

Other Notes

Chaussade, C., et al. 2007. Biochem. J.404, 449.
Cosemans, J.M, et al. 2006. Blood108, 3045.
Condliffe, A.M., et al. 2005. Blood106, 1432.
Jackson, S.P., et al. 2005. Nat. Med.11, 507.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c