C-005

Codeine-D₃ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Formula empirica (notazione di Hill): C₁₈H₁₈D₃NO₃
• Numero CAS: 70420-71-2
• Peso molecolare: 302.38
• Numero CE: 200-659-6
• Numero MDL: MFCD01075373
• Codice UNSPSC: 41116107
• ID PubChem: 329774759
• NACRES: NA.24

Proprietà

• Grado: certified reference material
• Forma fisica: liquid
• Caratteristiche: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• Confezionamento: ampule of 1 mL
• Produttore/marchio commerciale: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• Concentrazione: 100 μg/mL in methanol
• tecniche: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• applicazioni: forensics and toxicology
• Formato: single component solution
• Temperatura di conservazione: −20°C
• Stringa SMILE: [2H]C([2H])([2H])N1CC[C@]23[C@H]4Oc5c(OC)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O)c35
• InChI: 1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1/i1D3; OROGSEYTTFOCAN-SBGSAQJDSA-N

Descrizione

Descrizione generale

Codeine-D₃ is a stable-labeled internal standard suitable for many LC/MS or GC/MS testing applications including pain prescription monitoring, forensic analysis, clinical toxicology, urine drug testing or isotope dilution methods. Codeine is an opiate used for its analgesic, antitussive, and sedative properties and is the second-most predominant alkaloid in opium. Since opiate drugs are classified as controlled substances, Cerilliant offers most opiate reference standards as DEA-exempt solutions for added convenience.

Applicazioni

• A Novel Bioanalytical Method: This research introduces a novel bioanalytical method for determining opioids in blood and pericardial fluid, highlighting the importance of Codeine-D₃ as a reliable internal standard for precise quantification in forensic and clinical settings (Ferreira et al., 2020).


• GC-Triple Quadrupole MS Assay: A gas chromatography-triple quadrupole mass spectrometry assay developed for quantifying opiates in human blood samples employs Codeine-D₃, demonstrating its utility in enhancing detection sensitivity and accuracy in toxicological analyses (Saad et al., 2019).


• Comparison of Mass Analyzers: This study compares different mass analyzers for quantifying opioids in human plasma, where Codeine-D₃ serves as a critical component for ensuring measurement consistency across platforms, facilitating comprehensive pharmacokinetic studies (Viaene et al., 2016).


• Electrospray LC-MS Method: An electrospray LC-MS method with solid-phase extraction is employed for accurate determination of morphine, codeine, and their glucuronides in urine, with Codeine-D₃ used to improve the reliability of drug testing protocols (Svensson et al., 2007).


• Validation of LC-MS/MS for Opiate Confirmation: This study validates a direct injection electrospray LC-MS/MS technique for confirming opiates in urine, where Codeine-D₃ is integral for certifying the method′s efficacy, enhancing both forensic and clinical drug testing (Gustavsson et al., 2007).

Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H301 + H311 + H331,H370
• Consigli di prudenza: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organi bersaglio: Eyes,Central nervous system
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): 49.5 °F - closed cup
• Punto d’infiammabilità (°C): 9.7 °C - closed cup