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Merck

SHC1

SHC (Src homology 2 domain containing) transforming protein 1

Sinonimi:
SHC, SHCA
Specie:
ID UniProtKB:
ID gene:
  • Human(6464) Summary: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
  • Mouse(20416) src homology 2 domain-containing transforming protein C1
  • Rat(85385) SHC (Src homology 2 domain containing) transforming protein 1
  • Zebrafish(323818) SHC (Src homology 2 domain containing) transforming protein 1
  • naked mole-rat(101717434) SHC (Src homology 2 domain containing) transforming protein 1
  • domestic guinea pig(100734561) SHC (Src homology 2 domain containing) transforming protein 1
  • cow(507196) SHC (Src homology 2 domain containing) transforming protein 1
  • sheep(101113548) SHC (Src homology 2 domain containing) transforming protein 1
  • Horse(100063053) SHC (Src homology 2 domain containing) transforming protein 1
  • domestic cat(101092911) SHC (Src homology 2 domain containing) transforming protein 1
  • dog(490439) SHC (Src homology 2 domain containing) transforming protein 1
  • chicken(395934) SHC (Src homology 2 domain containing) transforming protein 1

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Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-Pan Shc Antibody, clone 3A12.1, clone 3A12.1, from mouse,
Reattività con
human
Applicazione
immunohistochemistry
western blot
Anti-p66shc Antibody, clone BG8, ,
Reattività con
human, mouse
Applicazione
immunocytochemistry
immunofluorescence

western blot
Anti-SHC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
Anti-phospho-SHC1 (pTyr349) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse
Applicazione
immunofluorescence
western blot
Anti-Phospho-SHC1-Y427 antibody produced in rabbit, ,
Reattività con
human, mouse
Applicazione
western blot

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting human SHC1,
Specie
human
MISSION® esiRNA, targeting mouse Shc1,
Specie
mouse