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Merck

PDE3A

phosphodiesterase 3A, cGMP-inhibited

Sinonimi:
CGI-PDE, CGI-PDE A, CGI-PDE-A
Specie:
ID UniProtKB:
ID gene:
  • Human(5139) Summary: This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
  • Mouse(54611) phosphodiesterase 3A, cGMP inhibited
  • Rat(50678) phosphodiesterase 3A, cGMP inhibited
  • domestic cat(101088586) phosphodiesterase 3A, cGMP-inhibited
  • naked mole-rat(101704787) phosphodiesterase 3A, cGMP-inhibited
  • Domestic Rabbit(100009330) phosphodiesterase 3A, cGMP-inhibited
  • Horse(100034086) phosphodiesterase 3A, cGMP-inhibited
  • sheep(101115870) phosphodiesterase 3A, cGMP-inhibited
  • Zebrafish(567051) phosphodiesterase 3A, cGMP-inhibited
  • cow(536636) phosphodiesterase 3A, cGMP-inhibited
  • chicken(418185) phosphodiesterase 3A, cGMP-inhibited
  • domestic guinea pig(100302667) phosphodiesterase 3A, cGMP inhibited

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Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-PDE3A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry

western blot
Anti-PDE3A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry
Monoclonal Anti-PDE3A antibody produced in mouse, clone 5C12, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
western blot

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
Cilostazol, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Milrinone, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Cilostazol, Pharmaceutical Secondary Standard; Certified Reference Material,
Specie
human
Amrinone, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Cilostazol, ≥98% (HPLC), powder,
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting human PDE3A,
Specie
human
MISSION® esiRNA, targeting mouse Pde3a,
Specie
mouse