PAX5
paired box 5
Sinonimi:
BSAP
Specie:
Human PAX5 (5079), Mouse Pax5 (18507), Rat Pax5 (500453), sheep PAX5 (101108719), domestic guinea pig Pax5 (100736213), naked mole-rat Pax5 (101700088), Zebrafish pax5 (60636), chicken PAX5 (387330), dog PAX5 (612021), domestic cat PAX5 (101089303) ...Più
ID UniProtKB:
ID gene:
- Human(5079) Summary: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
- Mouse(18507) paired box gene 5
- Rat(500453) paired box 5
- sheep(101108719) paired box 5
- domestic guinea pig(100736213) paired box 5
- naked mole-rat(101700088) paired box 5
- Zebrafish(60636) paired box gene 5
- chicken(387330) paired box 5
- dog(612021) paired box 5
- domestic cat(101089303) paired box 5
- Horse(100055252) paired box 5
- cow(538371) paired box 5
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-PAX5 Antibody, clone 4I0X4, Rabbit Monoclonal, ,
Reattività con
human
Applicazione
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
PAX-5 (SP34) Rabbit Monoclonal Antibody, ,
Reattività con
human
Applicazione
immunohistochemistry
Anti-PAX5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
Anti-PAX-5 antibody, Rabbit monoclonal, clone SP34, recombinant, expressed in proprietary host, affinity isolated antibody,
Reattività con
chicken, dog, human, mouse
Applicazione
flow cytometry
immunohistochemistry
immunohistochemistry
esiRNA
N° Catalogo
Descrizione
Specie