LIMK1
LIM domain kinase 1
Sinonimi:
LIMK, LIMK-1
Specie:
Human LIMK1 (3984), Mouse Limk1 (16885), Rat Limk1 (65172), domestic cat LIMK1 (101097861), Domestic Rabbit LIMK1 (100344018), dog LIMK1 (489800), Horse LIMK1 (100062100), naked mole-rat Limk1 (101698555), domestic guinea pig Limk1 (100712921), chicken LIMK1 (373922) ...Più
ID UniProtKB:
ID gene:
- Human(3984) Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
- Mouse(16885) LIM-domain containing, protein kinase
- Rat(65172) LIM domain kinase 1
- domestic cat(101097861) LIM domain kinase 1
- Domestic Rabbit(100344018) LIM domain kinase 1
- dog(489800) LIM domain kinase 1
- Horse(100062100) LIM domain kinase 1
- naked mole-rat(101698555) LIM domain kinase 1
- domestic guinea pig(100712921) LIM domain kinase 1
- chicken(373922) LIM domain kinase 1
- fruit fly(32207) LIM-kinase1
- sheep(101110900) LIM domain kinase 1
- cow(535225) LIM domain kinase 1
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Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-phospho-LIMK1 (pThr508) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-LIMK1 (pThr508) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
ANTI-LIMK1 antibody produced in mouse, clone 2E9, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Phospho-LIMK1-T508/LIMK2-T505 antibody produced in rabbit, ,
Reattività con
human
Applicazione
western blot
Anti-LIMK1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, ab1,
Reattività con
human
Applicazione
immunohistochemistry
western blot
western blot
Proteins
N° Catalogo
Descrizione
Specie
LIM Kinase 1 Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, human LIM Kinase 1, amino acids 285-638, for use in Kinase Assays.,
Specie
human
LIM Kinase 1 Protein, inactive, 50 g, Unactive, N-terminal 6His-tagged, recombinant, human LIM Kinase 1, amino acids 285-638. For use in Kinase Assays.,
Specie
human
esiRNA
N° Catalogo
Descrizione
Specie