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Merck

F12

coagulation factor XII (Hageman factor)

Sinonimi:
HAE3, HAEX, HAF
Specie:
ID UniProtKB:
ID gene:
  • Human(2161) Summary: This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]
  • Mouse(58992) coagulation factor XII (Hageman factor)
  • Rat(306761) coagulation factor XII (Hageman factor)
  • naked mole-rat(101720589) coagulation factor XII (Hageman factor)
  • domestic guinea pig(100728720) coagulation factor XII (Hageman factor)
  • Domestic Rabbit(100351481) coagulation factor XII (Hageman factor)
  • sheep(101106770) coagulation factor XII (Hageman factor)
  • cow(280789) coagulation factor XII (Hageman factor)
  • Horse(100068589) coagulation factor XII (Hageman factor)
  • domestic cat(100313488) coagulation factor XII (Hageman factor)
  • dog(489090) coagulation factor XII (Hageman factor)

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Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-Factor XII Antibody, clone 9A2, clone 9A2, from mouse,
Reattività con
baboon, human
Applicazione
ELISA
western blot
Anti-F12 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
western blot
Anti-Factor XII Antibody, clone 15H8, clone 15H8, from mouse,
Reattività con
baboon, human
Applicazione
ELISA
western blot
Anti-FA12 (heavy chain, Cleaved-Arg372) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human
Applicazione
ELISA
western blot
Monoclonal Anti-F12 antibody produced in mouse, clone 3A3, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
proximity ligation assay

western blot

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting human F12,
Specie
human
MISSION® esiRNA, targeting mouse F12,
Specie
mouse