CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4
Sinonimi:
CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1
Specie:
Human CYP3A4 (1576), Horse CYP3A4 (100294525), cow CYP3A4 (507988), dog CYP3A4 (479740), chicken CYP3A4 (416477)
ID UniProtKB:
ID gene:
- Human(1576) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
- Horse(100294525) cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
- cow(507988) cytochrome P450, subfamily IIIA, polypeptide 4
- dog(479740) cytochrome P450, family 3, subfamily A, polypeptide 4
- chicken(416477) cytochrome P450, family 3, subfamily A, polypeptide 4
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Antibodies
Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-CYP3A4 Antibody, clone 2F2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
human
Applicazione
affinity binding assay
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-CYP3A4 antibody produced in mouse, clone 3H8, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
flow cytometry
immunofluorescence
immunohistochemistry
western blot
flow cytometry
immunofluorescence
immunohistochemistry
western blot
Anticorpo anti-enzima citocromo P450 CYP3A4, serum, Chemicon®,
Reattività con
human, mammals, pig, rat
Applicazione
immunohistochemistry
western blot
western blot
Anti-CYP3A4 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Reattività con
human
Applicazione
immunohistochemistry
western blot
western blot
Anti-CYP3A4 antibody produced in rabbit, ,
Reattività con
human, mouse, rat
Applicazione
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Proteins
Numero di prodotto
Descrizione
Specie
Cytochrome P450 human, 3A4 isozyme microsomes, with P450 reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4),
Specie
human
esiRNA
Numero di prodotto
Descrizione
Specie