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V4390

Sigma-Aldrich

VUF 8430 dihydrobromide

≥97% (NMR)

Synonym(s):

2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester, S-(2-guanidylethyl)-isothiourea

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About This Item

Empirical Formula (Hill Notation):
C4H11N5S· 2HBr
CAS Number:
100130-32-3
Molecular Weight:
323.05
MDL number:
MFCD01694605
UNSPSC Code:
12352200
PubChem Substance ID:
329829051
NACRES:
NA.77

€78.40

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Quality Level

100

Assay

≥97% (NMR)

form

solid

storage condition

desiccated

solubility

deionized water: 24 mg/mL

storage temp.

room temp

SMILES string

Br.Br.NC(=N)NCCSC(N)=N

InChI

1S/C4H11N5S.2BrH/c5-3(6)9-1-2-10-4(7)8;;/h1-2H2,(H3,7,8)(H4,5,6,9);2*1H

InChI key

GPWJSTKHQMIXCA-UHFFFAOYSA-N

Biochem/physiol Actions

VUF 8430 dihydrobromide is a potent histamine H4 receptor agonist, with a 33-fold selectivity over the histamine H3 receptor and negligible affinity for the other histamine receptor.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
030M4733V
030M4733

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Tamara E Galarza et al.
Biochemical pharmacology, 180, 114177-114177 (2020-07-30)
Epithelial-mesenchymal transition (EMT) contributes to cell invasion and metastasis during the progression of epithelial cancers. Though preclinical evidence suggests a role for histamine H4 receptor (H4R) in breast cancer growth, its function in the EMT is less known. In this

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