U5625

Uridine 5′-diphosphoglucuronic acid ammonium salt

98-100%

• Synonym(s): UDP-GlcA, UDPGA, Uridine-diphosphate-glucuronic acid ammonium salt, Uridine[5′]diphospho[1]-α-D-glucopyranosuronic acid ammonium salt
• Empirical Formula (Hill Notation): C₁₅H₂₂N₂O₁₈P₂ · xNH₃
• CAS Number: 43195-60-4
• Molecular Weight: 580.29 (free acid basis)
• UNSPSC Code: 41106305
• PubChem Substance ID: 24900657
• NACRES: NA.51

Properties

• biological source: Saccharomyces cerevisiae; enzyme from bovine liver (catalase); enzyme from rabbit muscle (LDH)
• Assay: 98-100%
• form: powder
• storage temp.: −20°C
• SMILES string: N.O[C@@H]1[C@@H](O)[C@H](O[C@@H]([C@H]1O)C(O)=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O
• InChI: 1S/C15H22N2O18P2.H3N/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25;/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26);1H3/t4-,6-,7+,8+,9-,10-,11+,12-,14-;/m1./s1
• InChI key: WMWKTCPGFOEPBD-YGIWDPDDSA-N

Description

General description

Uridine 5′-diphosphoglucuronic acid (UDPGA) is a cofactor, synthesized from UDPglucose and nicotinamide adenine dinucleotide (NAD⁺) intracellularly by the catalytic activity of UDPglucose dehydrogenase. The concentration of UDPGA in a number of liver preparations ranges from 0.3-0.5 mM.

Application

Uridine 5′-diphosphoglucuronic acid ammonium salt has been used in the initiation of UDP-glucuronosyl transferase (UDGPT) assay towards ¹⁴C-testosterone in the liver S9 protein. It is suitable for use in UDGPT assay.

Biochem/physiol Actions

Uridine 5′-diphosphoglucuronic acid (UDGPA) is the glucuronic acid donor for the conjugation of bilirubin in the endoplasmic recticulum.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves