SRP0362
CHK2 active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)
Synonym(s):
CDS1, LFS2, RAD53, checkpoint kinase 2
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
Assay
≥70% (SDS-PAGE)
form
aqueous solution
mol wt
91 kDa
packaging
pkg of 10 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CHEK2(11200)
General description
Human Checkpoint kinase 2 (GenBank Accession No. NM_007194), full length with N-terminal HIS-tag, MW=91kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Travis H Stracker et al.
Cell cycle (Georgetown, Tex.), 7(23), 3618-3621 (2008-11-26)
Central to the DNA damage response (DDR) is the highly conserved Mre11 complex consisting of Mre11, Rad50 and Nbs1. The Mre11 complex acts as a sensor of DNA double-strand breaks (DSBs) and regulates the signal transduction cascades that are triggered
Reinhardt HC and Yaffe MB.
Current Opinion in Cell Biology (2009)
Qi-Qiang Guo et al.
The EMBO journal, 39(10), e103111-e103111 (2020-03-19)
The homeostatic link between oxidative stress and autophagy plays an important role in cellular responses to a wide variety of physiological and pathological conditions. However, the regulatory pathway and outcomes remain incompletely understood. Here, we show that reactive oxygen species
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