Product SRE0011 is suitable for the manufacturing of diagnostic reagents and kits. It must be stored at -20°C to maintain the 1-year warranty. Storage at 2-8°C is outside the recommended range, and the effect of prolonged storage at 2-8°C on the product's stability is unknown.
SRE0011
γ-Globulins from bovine blood
Suitable for manufacturing of diagnostic kits and reagents, ≥99% (agarose gel electrophoresis)
Synonym(s):
Bovine γ-Globulin
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1 G
€70.40
5 G
€232.00
10 G
€537.00
25 G
€939.00
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€2,860.00
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1 G
€70.40
5 G
€232.00
10 G
€537.00
25 G
€939.00
100 G
€2,860.00
About This Item
Recommended Products
Quality Level
Assay
≥99% (agarose gel electrophoresis)
form
powder
composition
NaCl, ≤4%
application(s)
diagnostic assay manufacturing
shipped in
wet ice
storage temp.
−20°C
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General description
γ-Globulins are immunoglobulins that contain IgM, IgA, and IgY.[1] They are glycoproteins produced by plasma cells.[2] The immunoglobulins are heterodimeric molecules comprising two light chains and two heavy chains linked together by disulfide bonds.[3]
Bovine gamma globulin (BGG) is an important component of the immune system of cows and other bovines. BGG is found in the blood of bovines and is primarily used in the production of medical products such as vaccines, serums, and diagnostic reagents. BGG can also be used to treat certain medical conditions, such as hepatitis B, as well as to boost immunity in humans and other animals.
Plasma protein fraction rich in antibodies
Application
γ-Globulins from bovine blood has been used along with polyethylene glycol (PEG) to investigate the kinetics of liquid-liquid phase separation (LLPS) in its temporary and arrested state.[4] It has also been used as a parent solution to prevent bacterial growth and study the antibody system with LLPS and highly elevated protein concentrations in arrested transition.[5]
Bovine γ-globulin has been used as an immunological challenge in studies of mechanisms of immunotolerance.
Biochem/physiol Actions
Immunoglobulins are implicated in the activation of the complement system and the opsonization of microbes for phagocytosis. It is also involved in the neutralization of toxins and viruses and blocks the attachment of microbes to mucosal surfaces. They protect our bodies against fungi, viruses, and bacteria. Immunodeficiency is associated with recurrent infectious diseases.[2]
Preparation Note
Prepared from Cohn Fraction II, III
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains. They can be separated functionally into variable domains that bind antigens and constant domains that specify effector functions, such as activation of complement or binding to Fc receptors.
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Can Gamma-Globulins be stored at 2 - 8 C without affecting shelf life, considering the Certificate of Analysis specifies a storage temperature of -20 C?
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Dear sir or madam, Can you please let me know what is the shelf life for this reference
1 answer-
This product is not assigned an expiration date. It is assigned a recommended retest date of 2 years after the quality release date. A recommended retest date is the time during which the product is expected to remain within established stability specifications, provided that it has been stored under defined conditions. After the Retest Date, product samples should be examined to ensure that the product is still in compliance with the established specifications.
For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.
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