SML3608
Massonianoside B
≥95% (HPLC)
Synonym(s):
4-[(2S,3R)-2,3-Dihydro-7-hydroxy-3-(hydroxymethyl)-5-(3-hydroxypropyl)-2-benzofuranyl]-2-methoxyphenyl 6-deoxy-α-L-mannopyranoside
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About This Item
Empirical Formula (Hill Notation):
C25H32O10
CAS Number:
Molecular Weight:
492.52
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.21
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Quality Level
Assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Cell-permeable, potent, highly selective, reversible and SAM-competitive DOT1L inhibitor
Massonianoside B is a cell-permeable, potent, highly selective, reversible and SAM-competitive DOT1L (disruptor of 4 telomeric silencing 1-like) inhibitor that decreases cellular levels of H3K79 methylation and inhibits the MLL fusion target genes HOXA9 and MEIS1 expression. Massonianoside B exhibits anti-leukemic activity. It is metabolically stable in both human and mouse liver microsomes.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Jie Chen et al.
ACS chemical biology, 14(5), 873-881 (2019-04-06)
Protein methyltransferases (PMTs) are involved in numerous biological processes and have been studied as a promising target class in the field of oncology and other diseases. Disruptor of telomeric silencing 1-like (DOT1L), a histone H3 lysine 79 (H3K79) methyltransferase, plays
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