SML2999
KL201
≥97% (HPLC)
Synonym(s):
2-Bromo-N-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)-benzamide
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C17H14BrN3OS
CAS Number:
Molecular Weight:
388.28
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=CC=CC=C1Br)NC2=NC=NC3=C2C4=C(CCCC4)S3
Biochem/physiol Actions
KL201 is a circadian clock modulator that lengthens a circadian period in cells and tissues. KL201 selectively regulate cryptochrome 1 (Cry1). It binds to FAD-binding pocket of CRY1 preventing interaction with FBXL3 and ubiquitin-dependent degradation.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Simon Miller et al.
Cell chemical biology, 27(9), 1192-1198 (2020-06-06)
Cryptochrome 1 (CRY1) and CRY2 are core regulators of the circadian clock, and the development of isoform-selective modulators is important for the elucidation of their redundant and distinct functions. Here, we report the identification and functional characterization of a small-molecule
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service