Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

SML0175

Sigma-Aldrich

Pyrovalerone hydrochloride

≥98% (HPLC)

Synonym(s):

1-(4-Methylphenyl)-2-(1-pyrrolidinyl)-1-pentanone hydrochloride, Centroton, F 1983, Sp 1059, Thymergix

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C16H23NO·HCl
CAS Number:
1147-62-2
Molecular Weight:
281.82
EC Number:
214-556-9
UNSPSC Code:
41116107
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

drug control

psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

color

off-white to light brown

solubility

H2O: ≥5 mg/mL at 60 °C

storage temp.

2-8°C

InChI

1S/C16H23NO.ClH/c1-3-6-15(17-11-4-5-12-17)16(18)14-9-7-13(2)8-10-14;/h7-10,15H,3-6,11-12H2,1-2H3;1H

InChI key

MWRACNBZNVAJHE-UHFFFAOYSA-N

Application

Pyrovalerone hydrochloride may be used in dopamine-mediated cell signaling studies.

Biochem/physiol Actions

Pyrovalerone hydrochloride is a CNS Stimulant; norepinephrine-dopamine reuptake inhibitor (NDRI)
Pyrovalerone hydrochloride is a rapidly-absorbed psychostimulant. It belongs to the class of synthetic cathinones often used as performance-enhancing agent by athletes before being banned.[1][2]
Pyrovalerone is a norepinephrine-dopamine reuptake inhibitor (NDRI) that acts as a CNS stimulant.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H336

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000078251
0000078252
101M4620V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Jane M Prosser et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 8(1), 33-42 (2011-11-24)
Synthetic cathinones have recently emerged and grown to be popular drugs of abuse. Their dramatic increase has resulted in part from sensationalized media attention as well as widespread availability on the Internet. They are often considered "legal highs" and sold
David J Lapinsky et al.
Bioorganic & medicinal chemistry, 17(11), 3770-3774 (2009-05-16)
Non-tropane-based photoaffinity ligands for the dopamine transporter (DAT) are relatively unexplored in contrast to tropane-based compounds such as cocaine. In order to fill this knowledge gap, a ligand was synthesized in which the aromatic ring of pyrovalerone was substituted with
C Héron et al.
European journal of pharmacology, 264(3), 391-398 (1994-11-03)
We have studied the ability of various uptake blockers to protect the dopamine neuronal carrier labeled with [3H]GBR 12783 (1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-(propenyl)-piperazine) against N-ethylmaleimide-induced alkylation, using membrane preparations obtained from rat striatum. Pure uptake inhibitors such as mazindol, pyrovalerone, nomifensine and methylphenidate
The metabolism of pyrovalerone hydrochloride.
W Michaelis et al.
Journal of medicinal chemistry, 13(3), 497-503 (1970-05-01)
D S Lho et al.
Journal of chromatography. B, Biomedical applications, 687(1), 253-259 (1996-12-06)
Pyrovalerone and its hydroxylated metabolite have been identified by gas chromatography-mass spectrometry in rat urine and plasma. A sensitive gas chromatographic method for the quantitative analysis of pyrovalerone in rat urine and plasma is described. The method also permits the
View All Related Papers

Articles

Dopamine Receptors

We offer many products related to dopamine receptors for your research needs.

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service