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SAB4503258

Sigma-Aldrich

Anti-Calnexin, C-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CALX, CANX, IP90, Major histocompatibility complex class I

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About This Item

MDL number:
MFCD01094399
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 67 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P27824

UniProt accession no.

P27824

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CANX(821)

General description

Anti-Calnexin Antibody detects endogenous levels of total Calnexin protein.

CANX (calnexin) is an endoplasmic reticulum (ER) chaperone. It has a molecular weight of 67kDa. It is a type I transmembrane protein and is located on human chromosome 5q35.

Immunogen

The antiserum was produced against synthesized peptide derived from human Calnexin.

Immunogen Range: 543-592

Biochem/physiol Actions

CANX (calnexin) participates in protein folding and quality control. It is responsible for glycan-independent interaction and retention of mutated Gas3/PMP22 (growth arrest-specific protein 3/peripheral myelin protein 22) proteins involved in Charcot-Marie-Tooth 1A and Dejerine Sottas syndrome.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mapping of primary congenital lymphedema to the 5q35.3 region
Evans AL, et al.
American Journal of Human Genetics, 64(2), 547-555 (1999)
Silvia G Inderbinen et al.
Toxicology letters, 322, 39-49 (2020-01-14)
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Hao Liu et al.
Cell biology international, 43(2), 167-173 (2018-12-15)
Cerebral dopamine neurotrophic factor (CDNF) has been considered as potent candidates for the therapy of Parkinson's disease (PD) for which can promote the survival of midbrain dopaminergic neurons. In addition to secret out from cells like other classical neurotrophic factors
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