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SAB4500753

Sigma-Aldrich

Anti-APOBEC3A antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Phorbolin-1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 23 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI accession no.

P31941

UniProt accession no.

P31941

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APOBEC3A(200315)

General description

APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) belongs to the AID/APOBEC family of enzymes. It is located on human chromosome 22q13.1.
Anti-APOBEC3A antibody detects endogenous levels of total APOBEC3A protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human APOBEC3A.

Immunogen Range: 27-76

Application

Anti-APOBEC3A antibody has been used in western blotting.

Biochem/physiol Actions

APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) deaminates methylated cytosine bases in DNA. It is considered as a viral DNA mutator and performs broad antiviral activity.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jan-Hendrik Bockmann et al.
The Journal of infectious diseases, 220(4), 567-577 (2019-03-30)
Type III interferons (IFNs) (λ1-3) activate similar signaling cascades as type I IFNs (α and β) via different receptors. Since IFN-α and lymphotoxin-β activate cytosine deamination and subsequent purging of nuclear hepatitis B virus (HBV) DNA, we investigated whether IFN-β
Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A
Aynaud MM, et al.
The Journal of Biological Chemistry (2012)
Heat Increases the Editing Efficiency of Human Papillomavirus E2 Gene by Inducing Upregulation of APOBEC3A and 3G
Yang Y, et al.
The Journal of Investigative Dermatology, 137(4), 810-818 (2017)
Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage
Suspene R, et al.
Nucleic Acids Research, 45(6), 3231-3241 (2017)
Marie-Ming Aynaud et al.
The Journal of biological chemistry, 287(46), 39182-39192 (2012-09-15)
The human polydeoxynucleotide cytidine deaminases APOBEC3A, APOBEC3C, and APOBEC3H are capable of mutating viral DNA in the nucleus, whereas APOBEC3A alone efficiently edits nuclear DNA. Deamination is rapidly followed by excision of uracil residues and can lead to double-stranded breaks.
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