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SAB4300456

Sigma-Aldrich

Anti-EFNB2 (Ab-330) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-EPLG5 antibody produced in rabbit, Anti-HTKL antibody produced in rabbit, Anti-Htk-L antibody produced in rabbit, Anti-LERK5 antibody produced in rabbit, Anti-ephrin-B2 antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~37 kDa

species reactivity

rat, mouse, human

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(N-I-Y-Y-K)

NCBI accession no.

NP_004084.1

UniProt accession no.

P52799

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... EFNB2(1948)

General description

EFNB2 (ephrin B2) is a membrane-bound molecule , that is located on human chromosome 13q33.

Immunogen

Peptide sequence around aa. 328-332 (N-I-Y-Y-K), according to the protein EFNB2.

Biochem/physiol Actions

EFNB2 (ephrin B2) regulates the development of arterial endothelial cell. It also modulates the movement and adherence of vascular smooth muscle cells and pericytes to the extending arterial endothelial cell tubes. Overexpression of EFNB2 results in low tumor stage and elevated expression of TrkA in neuroblastomas. It controls the growth of thymocyte and differentiation of peripheral T cell. It is required for interleukin-6 (IL-6) signaling. It also modulates the antiviral immune responses.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Ephrin-B2 encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a lycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Association analysis of the ephrin-B2 gene in African-Americans with end-stage renal disease
Hicks PJ, et al.
American Journal of Nephrology, 28(6), 914-920 (2008)
Efnb1 and Efnb2 proteins regulate thymocyte development, peripheral T cell differentiation, and antiviral immune responses and are essential for interleukin-6 (IL-6) signaling
Luo H, et al.
The Journal of Biological Chemistry, 286(48), 41135-41152 (2011)
High-level expression of EPHB6, EFNB2, and EFNB3 is associated with low tumor stage and high TrkA expression in human neuroblastomas
Tang XX, et al.
Clinical Cancer Research, 5(6), 1491-1496 (1999)
Jaeho Yoon et al.
Nature communications, 9(1), 3491-3491 (2018-08-30)
Although Eph-ephrin signalling has been implicated in the migration of cranial neural crest (CNC) cells, it is still unclear how ephrinB transduces signals regulating this event. We provide evidence that TBC1d24, a putative Rab35-GTPase activating protein (Rab35 GAP), complexes with

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