IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.
Immunogen
IGFBP3 (NP_036720, 168-203) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of rat IGFBP3.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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